During the process of differentiation, chondrocytes integrate a complex array of signals from
local or systemic factors like parathyroid hormone-related peptide (PTHrP), Indian
hedgehog, bone morphogenetic proteins and transforming growth factor β. While PTHrP is
known to be a critical regulator of chondrocyte proliferation and differentiation, the signaling
pathways through which this factor acts remain to be elucidated. Here we show that both
cAMP response element-binding protein (CREB) and AP-1 activation are critical to PTHrP …