Publisher Summary This chapter attempts to identify the principles and issues elucidated in
animal models that may provide insights for the development of effective approaches to
modulate T cell functions to promote the eradication of human tumors. The importance of T
cells in surveillance against the outgrowth of tumor cells is probably best demonstrated with
virally transformed tumors, such as EBV-induced B cell lymphomas, which occur with
markedly increased frequency in transplant patients specifically depleted of T cells, and with …