Human immunoglobulin κ light-chain genes are deleted or rearranged in λ-producing B cells
PA Hieter, SJ Korsmeyer, TA Waldmann, P Leder - Nature, 1981 - nature.com
PA Hieter, SJ Korsmeyer, TA Waldmann, P Leder
Nature, 1981•nature.comWe have examined 10 human λ light-chain-producing B lymphocytes and found that genes
for the κ constant region have been deleted in each. Only one of the 20 possible κ alleles in
these cells has been retained and even this exception is rearranged. In contrast, λ constant
region genes remain in the germ-line configuration in each of the eight κ light-chain-
producing human B lymphocytes examined. Such observations suggest a hierarchy of light-
chain-gene rearrangement beginning with κ and proceeding to λ.
for the κ constant region have been deleted in each. Only one of the 20 possible κ alleles in
these cells has been retained and even this exception is rearranged. In contrast, λ constant
region genes remain in the germ-line configuration in each of the eight κ light-chain-
producing human B lymphocytes examined. Such observations suggest a hierarchy of light-
chain-gene rearrangement beginning with κ and proceeding to λ.
Abstract
We have examined 10 human λ light-chain-producing B lymphocytes and found that genes for the κ constant region have been deleted in each. Only one of the 20 possible κ alleles in these cells has been retained and even this exception is rearranged. In contrast, λ constant region genes remain in the germ-line configuration in each of the eight κ light-chain-producing human B lymphocytes examined. Such observations suggest a hierarchy of light-chain-gene rearrangement beginning with κ and proceeding to λ.
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