[HTML][HTML] Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases: identification and characterization of a signaling pathway to the nucleus
S Kamakura, T Moriguchi, E Nishida - Journal of Biological Chemistry, 1999 - ASBMB
ERK5 (also known as BMK1), a member of the mitogen-activated protein kinase (MAPK)
superfamily, was known to be activated strongly by oxidant and osmotic stresses. Here we
have found that ERK5 is strongly activated by epidermal growth factor and nerve growth
factor, whose receptors are tyrosine kinases. The activation of ERK5 was inhibited by
expression of dominant-negative Ras and induced by expression of active Ras in PC12
cells, indicating a requirement for Ras in ERK5 activation. The epidermal growth factor …
superfamily, was known to be activated strongly by oxidant and osmotic stresses. Here we
have found that ERK5 is strongly activated by epidermal growth factor and nerve growth
factor, whose receptors are tyrosine kinases. The activation of ERK5 was inhibited by
expression of dominant-negative Ras and induced by expression of active Ras in PC12
cells, indicating a requirement for Ras in ERK5 activation. The epidermal growth factor …
