Administration of an anti-interleukin 2 receptor monoclonal antibody prolongs cardiac allograft survival in mice.
RL Kirkman, LV Barrett, GN Gaulton… - The Journal of …, 1985 - europepmc.org
RL Kirkman, LV Barrett, GN Gaulton, VE Kelley, A Ythier, TB Strom
The Journal of experimental medicine, 1985•europepmc.orgAdministration of the monoclonal antibody M7/20, which binds to the murine interleukin-2
(IL) receptor, significantly prolongs cardiac allograft survival in two H-2-incompatible strain
combinations of inbred mice. The results support the important role of the IL-2 receptor in the
mechanism of graft rejection, and suggest its suitability as a target for immunosuppressive
therapy.
(IL) receptor, significantly prolongs cardiac allograft survival in two H-2-incompatible strain
combinations of inbred mice. The results support the important role of the IL-2 receptor in the
mechanism of graft rejection, and suggest its suitability as a target for immunosuppressive
therapy.
Abstract
Administration of the monoclonal antibody M7/20, which binds to the murine interleukin-2 (IL) receptor, significantly prolongs cardiac allograft survival in two H-2-incompatible strain combinations of inbred mice. The results support the important role of the IL-2 receptor in the mechanism of graft rejection, and suggest its suitability as a target for immunosuppressive therapy.
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