[HTML][HTML] Two waves of platelet secretion induced by thromboxane A2 receptor and a critical role for phosphoinositide 3-kinases
Thromboxane A 2 (TXA 2)-mediated platelet secretion and aggregation are important in
thrombosis. Here, we present a novel finding that the stable TXA 2 analogue, U46619,
induces two waves of platelet secretion, each of which precedes a distinct wave of platelet
aggregation. ADP released from platelets during the first wave of secretion played a major
role in augmenting the first wave of platelet aggregation. The second wave of platelet
secretion and aggregation required the first wave of both ADP secretion and aggregation …
thrombosis. Here, we present a novel finding that the stable TXA 2 analogue, U46619,
induces two waves of platelet secretion, each of which precedes a distinct wave of platelet
aggregation. ADP released from platelets during the first wave of secretion played a major
role in augmenting the first wave of platelet aggregation. The second wave of platelet
secretion and aggregation required the first wave of both ADP secretion and aggregation …