[HTML][HTML] Growth Hormone-promoted Tyrosyl Phosphorylation of SHC Proteins and SHC Association with Grb2 (∗)
J VanderKuur, G Allevato, N Billestrup… - Journal of Biological …, 1995 - ASBMB
Growth hormone (GH) has been shown to stimulate the mitogen-activated protein (MAP)
kinases designated ERKs (extracellular signal regulated kinases) 1 and 2. One pathway by
which ERKs 1 and 2 are activated by tyrosine kinases involves the Src homology (SH)-2
containing proteins SHC and Grb2. To gain insight into pathways coupling GH receptor
(GHR) to MAP kinase activation and signaling molecules that might interact with GHR and its
associated tyrosine kinase JAK2, we examined whether SHC and Grb2 proteins serve as …
kinases designated ERKs (extracellular signal regulated kinases) 1 and 2. One pathway by
which ERKs 1 and 2 are activated by tyrosine kinases involves the Src homology (SH)-2
containing proteins SHC and Grb2. To gain insight into pathways coupling GH receptor
(GHR) to MAP kinase activation and signaling molecules that might interact with GHR and its
associated tyrosine kinase JAK2, we examined whether SHC and Grb2 proteins serve as …
