Adhesions of lymphocytes, among themselves or with other cell types, are necessary for
most steps in immune responses including both induction and effector phases. Among
adhesions of T cells involving specific immunological recognition, CTL-target adhesions
have been the most studied. Although CTL-mediated killing is highly specific
(specific/nonspecific lytic activity 50-fold), CTL-target adhesion (conjugation) is less so. In
the mouse, specificity of conjugation has typically been four to eightfold. Two recent studies …