The ingestion of inorganic nitrate increases gastric S-nitrosothiol levels and inhibits platelet function in humans
G Richardson, SL Hicks, S O'Byrne, MT Frost, K Moore… - Nitric Oxide, 2002 - Elsevier
Platelets play an important role in the development of vascular disease, while vegetarian
diets, which are rich in inorganic nitrate, protect against it. This study was performed to
assess the effect of potassium nitrate (KNO3) ingestion on platelet function in humans. Oral
KNO3 (2mmol) was given to healthy volunteers and its effect on platelet function assessed
by measuring the aggregant effect of collagen. Blood samples were taken for measurement
of plasma S-nitrosothiols (RSNO) and platelet cyclic GMP and nitrotyrosine levels. Gastric …
diets, which are rich in inorganic nitrate, protect against it. This study was performed to
assess the effect of potassium nitrate (KNO3) ingestion on platelet function in humans. Oral
KNO3 (2mmol) was given to healthy volunteers and its effect on platelet function assessed
by measuring the aggregant effect of collagen. Blood samples were taken for measurement
of plasma S-nitrosothiols (RSNO) and platelet cyclic GMP and nitrotyrosine levels. Gastric …
