[HTML][HTML] Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-κB …
SK Manna, HJ Zhang, T Yan, LW Oberley… - Journal of Biological …, 1998 - ASBMB
Several recently identified intracellular proteins associate with the tumor necrosis factor
(TNF) receptor and activate nuclear transcription factor (NF)-κB, c-Jun kinase, and
apoptosis. However, the mechanism is not understood. In the present report, we investigated
the role of reactive oxygen intermediates in TNF-induced signaling. Overexpression of
manganese superoxide dismutase (Mn-SOD) in human breast cancer MCF-7 cells
completely abolished TNF-mediated NF-κB activation, IκBα degradation, p65 nuclear …
(TNF) receptor and activate nuclear transcription factor (NF)-κB, c-Jun kinase, and
apoptosis. However, the mechanism is not understood. In the present report, we investigated
the role of reactive oxygen intermediates in TNF-induced signaling. Overexpression of
manganese superoxide dismutase (Mn-SOD) in human breast cancer MCF-7 cells
completely abolished TNF-mediated NF-κB activation, IκBα degradation, p65 nuclear …