Activated CD8+ T cells in secondary progressive MS secrete lymphotoxin
GJ Buckle, P Höllsberg, DA Hafler - Neurology, 2003 - AAN Enterprises
GJ Buckle, P Höllsberg, DA Hafler
Neurology, 2003•AAN EnterprisesThe authors compared the functional activation state and cytokine secretion profile of CD8+
T cells in patients with relapsing-remitting and secondary progressive (SP) MS to those in
normal controls. In addition, they examined cytokine secretion in relationship to single
nucleotide polymorphism (SNP) analysis of cytokine genes. A significant increase in
lymphotoxin secretion from anti-CD3-stimulated CD8+ T cells was observed in patients with
SPMS as compared to normal controls. The authors found no significant differences in SNP …
T cells in patients with relapsing-remitting and secondary progressive (SP) MS to those in
normal controls. In addition, they examined cytokine secretion in relationship to single
nucleotide polymorphism (SNP) analysis of cytokine genes. A significant increase in
lymphotoxin secretion from anti-CD3-stimulated CD8+ T cells was observed in patients with
SPMS as compared to normal controls. The authors found no significant differences in SNP …
The authors compared the functional activation state and cytokine secretion profile of CD8+ T cells in patients with relapsing-remitting and secondary progressive (SP) MS to those in normal controls. In addition, they examined cytokine secretion in relationship to single nucleotide polymorphism (SNP) analysis of cytokine genes. A significant increase in lymphotoxin secretion from anti-CD3-stimulated CD8+ T cells was observed in patients with SPMS as compared to normal controls. The authors found no significant differences in SNP frequency or in secretion of other cytokines.
American Academy of Neurology