Expression of messenger RNA for amphiregulin, heregulin, and cripto-1, three new members of the epidermal growth factor family, in human breast carcinomas
N Normanno, N Kim, D Wen, K Smith, AL Harris… - Breast cancer research …, 1995 - Springer
Breast cancer research and treatment, 1995•Springer
The expression of amphiregulin (AR), heregulin (HRG), and cripto-1 (CR-1) mRNA
transcripts was assessed in 60 human primary breast carcinoma. AR and HRG transcripts
were expressed respectively in 58% and 25% of the carcinomas as measured by Northern
blot analysis. CR-1 mRNA was found in 77% of the carcinomas using Reverse Transcriptase-
PCR analysis. Coexpression of two or three of these peptides was observed in several
specimens. There was no significant association between AR, HRG, and CR-1 expression …
transcripts was assessed in 60 human primary breast carcinoma. AR and HRG transcripts
were expressed respectively in 58% and 25% of the carcinomas as measured by Northern
blot analysis. CR-1 mRNA was found in 77% of the carcinomas using Reverse Transcriptase-
PCR analysis. Coexpression of two or three of these peptides was observed in several
specimens. There was no significant association between AR, HRG, and CR-1 expression …
Abstract
The expression of amphiregulin (AR), heregulin (HRG), and cripto-1 (CR-1) mRNA transcripts was assessed in 60 human primary breast carcinoma. AR and HRG transcripts were expressed respectively in 58% and 25% of the carcinomas as measured by Northern blot analysis. CR-1 mRNA was found in 77% of the carcinomas using Reverse Transcriptase-PCR analysis. Coexpression of two or three of these peptides was observed in several specimens. There was no significant association between AR, HRG, and CR-1 expression and nodal status, EGF receptor, or c-erbB-2 protooncogene expression in these tumors. However, a significant association between AR expression and estrogen receptor positivity was observed.
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