Heterotrimeric G protein signaling: role in asthma and allergic inflammation
EN Johnson, KM Druey - Journal of allergy and clinical immunology, 2002 - Elsevier
Asthma and rhinitis are pathophysiologic conditions associated with a prototypical allergic
response to inhaled allergens consisting of both neuromechanical and inflammatory
components. Heptahelical receptors that bind guanosine triphosphate–binding proteins (G
proteins), referred to as G protein–coupled receptors (GPCRs), have been intimately linked
with asthma and allergic inflammation for many years. G protein signaling mediates
responses throughout the immune, nervous, and muscular systems that might contribute to …
response to inhaled allergens consisting of both neuromechanical and inflammatory
components. Heptahelical receptors that bind guanosine triphosphate–binding proteins (G
proteins), referred to as G protein–coupled receptors (GPCRs), have been intimately linked
with asthma and allergic inflammation for many years. G protein signaling mediates
responses throughout the immune, nervous, and muscular systems that might contribute to …
