Dual Effect of β-Adrenergic Receptors on Mitogen-activated Protein Kinase: EVIDENCE FOR A βγ-DEPENDENT ACTIVATION AND A Gαs-cAMP-MEDIATED …
P Crespo, TG Cachero, N Xu, JS Gutkind - Journal of Biological Chemistry, 1995 - ASBMB
The enzymatic activity of mitogen-activated protein kinases (MAP kinases) increases in
response to agents acting on a variety of cell surface receptors, including receptors linked to
heterotrimeric G proteins of the G i and G q family. Recently, it has been shown that
stimulation of β-adrenergic receptors, which are typical of those that act through G s to
activate adenylyl cyclases, potently activates MAP kinases in the heart, resulting in the
hypertrophy of the cardiac muscle (Lazou, A., Bogoyevitch, MA, Clerk, A., Fuller, SJ …
response to agents acting on a variety of cell surface receptors, including receptors linked to
heterotrimeric G proteins of the G i and G q family. Recently, it has been shown that
stimulation of β-adrenergic receptors, which are typical of those that act through G s to
activate adenylyl cyclases, potently activates MAP kinases in the heart, resulting in the
hypertrophy of the cardiac muscle (Lazou, A., Bogoyevitch, MA, Clerk, A., Fuller, SJ …
