Selective recognition of a CG base-pair in the parallel DNA triple-helical binding motif
I Prévot-Halter, CJ Leumann - Bioorganic & medicinal chemistry letters, 1999 - Elsevier
I Prévot-Halter, CJ Leumann
Bioorganic & medicinal chemistry letters, 1999•ElsevierSelective recognition of a CG base-pair within the parallel DNA triple-helical binding motif
was achieved by a third strand containing the base 5-methyl pyrimidin-2-one. The third
strand affinities (KD) for a representative 15-mer duplex sequence containing all four
Watson-Crick base pairs (XY) in the center are CG (26 nM)⪢ AT (270 nM)∼ TA (350 nM)>
GC (ca. 700 nM).
was achieved by a third strand containing the base 5-methyl pyrimidin-2-one. The third
strand affinities (KD) for a representative 15-mer duplex sequence containing all four
Watson-Crick base pairs (XY) in the center are CG (26 nM)⪢ AT (270 nM)∼ TA (350 nM)>
GC (ca. 700 nM).
Selective recognition of a C-G base-pair within the parallel DNA triple-helical binding motif was achieved by a third strand containing the base 5-methyl pyrimidin-2-one. The third strand affinities (KD) for a representative 15-mer duplex sequence containing all four Watson-Crick base pairs (X-Y) in the center are C-G (26 nM) ⪢ A-T (270 nM) ∼ T-A (350 nM) > G-C (ca. 700 nM).
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