[HTML][HTML] Triplex-induced recombination in human cell-free extracts: Dependence on XPA and HsRad51
HJ Datta, PP Chan, KM Vasquez, RC Gupta… - Journal of Biological …, 2001 - ASBMB
Triple helix-forming oligonucleotides (TFOs) can bind to polypurine/polypyrimidine regions
in DNA in a sequence-specific manner. Triple helix formation has been shown to stimulate
recombination in mammalian cells in both episomal and chromosomal targets containing
direct repeat sequences. Bifunctional oligonucleotides consisting of a recombination donor
domain tethered to a TFO domain were found to mediate site-specific recombination in an
intracellular SV40 vector target. To elucidate the mechanism of triplex-induced …
in DNA in a sequence-specific manner. Triple helix formation has been shown to stimulate
recombination in mammalian cells in both episomal and chromosomal targets containing
direct repeat sequences. Bifunctional oligonucleotides consisting of a recombination donor
domain tethered to a TFO domain were found to mediate site-specific recombination in an
intracellular SV40 vector target. To elucidate the mechanism of triplex-induced …