A cytosine analogue containing a conformationally flexible acyclic linker for triplex formation at sites with contiguous GC base pairs
G Xiang, LW McLaughlin - Tetrahedron, 1998 - Elsevier
Two nucleoside derivatives of the pyrimidine bases T and m5oxC have been prepared with
flexible acyclic carbohydrate linkers. A new procedure, beginning with (R)-(−)-2, 2-dimethyl-
1, 3-dioxolane-4-methanol permits the preparation of the stereochemically pure acyclic
derivatives of both protected nucleoside analogues without contamination by a problematic
rearrangement product. By simply increasing the flexibility of the carbohydrate portion of the
am5oxC nucleoside derivative, 15-mer triplexes containing five contiguous GC base pairs …
flexible acyclic carbohydrate linkers. A new procedure, beginning with (R)-(−)-2, 2-dimethyl-
1, 3-dioxolane-4-methanol permits the preparation of the stereochemically pure acyclic
derivatives of both protected nucleoside analogues without contamination by a problematic
rearrangement product. By simply increasing the flexibility of the carbohydrate portion of the
am5oxC nucleoside derivative, 15-mer triplexes containing five contiguous GC base pairs …