Differential selection of multidrug efflux systems by quinolones in Pseudomonas aeruginosa
T Köhler, M Michea-Hamzehpour… - Antimicrobial agents …, 1997 - Am Soc Microbiol
T Köhler, M Michea-Hamzehpour, P Plesiat, AL Kahr, JC Pechere
Antimicrobial agents and chemotherapy, 1997•Am Soc MicrobiolResistance mechanisms selected after in vitro exposure to 12 quinolones were analyzed for
Pseudomonas aeruginosa. Efflux-type mutants were predominant. Quinolones differed in
their ability to select a particular efflux system. While the newer fluoroquinolones favored the
MexCD-OprJ system, the older quinolones selected exclusively the MexEF-OprN or MexAB-
OprM systems. A protonable C-7 substituent in combination with a C-6 fluorine atom is a
structural determinant of quinolones involved in efflux pump substrate specificity.
Pseudomonas aeruginosa. Efflux-type mutants were predominant. Quinolones differed in
their ability to select a particular efflux system. While the newer fluoroquinolones favored the
MexCD-OprJ system, the older quinolones selected exclusively the MexEF-OprN or MexAB-
OprM systems. A protonable C-7 substituent in combination with a C-6 fluorine atom is a
structural determinant of quinolones involved in efflux pump substrate specificity.
Resistance mechanisms selected after in vitro exposure to 12 quinolones were analyzed for Pseudomonas aeruginosa. Efflux-type mutants were predominant. Quinolones differed in their ability to select a particular efflux system. While the newer fluoroquinolones favored the MexCD-OprJ system, the older quinolones selected exclusively the MexEF-OprN or MexAB-OprM systems. A protonable C-7 substituent in combination with a C-6 fluorine atom is a structural determinant of quinolones involved in efflux pump substrate specificity.
American Society for Microbiology