The role of novel T cell costimulatory pathways in autoimmunity and transplantation
A Yamada, AD Salama, MH Sayegh - Journal of the American …, 2002 - journals.lww.com
The CD28-B7 and CD154-CD40 pathways have been described as the critical costimulatory
pathways for T cell activation. Blockade of these pathways has been reported to regulate
both autoimmune and alloimmune responses in experimental models and in human
disease. However, studies have indicated that inhibition of these pathways is insufficient to
reproducibly induce long-lasting immunologic tolerance in experimental autoimmunity and
transplantation models. This suggests that host immune reactivity toward the autoantigens or …
pathways for T cell activation. Blockade of these pathways has been reported to regulate
both autoimmune and alloimmune responses in experimental models and in human
disease. However, studies have indicated that inhibition of these pathways is insufficient to
reproducibly induce long-lasting immunologic tolerance in experimental autoimmunity and
transplantation models. This suggests that host immune reactivity toward the autoantigens or …
