Epidermal growth factor and lipopolysaccharide activate Stat3 transcription factor in mouse liver.
Previous studies demonstrated that the intraperitoneal injection of epidermal growth factor
(EGF) into mice resulted in the appearance, within minutes, of several tyrosine-
phosphorylated proteins in liver nuclei. Two of these proteins have been identified as the
transcription factors p91/p84 (Stat1 alpha/1 beta)(Ruff-Jamison, S., Chen, K., and Cohen,
S.(1993) Science 261, 1733-1736). We have now identified, by Western blotting and
immunoprecipitation, an additional EGF-modulated transcription factor, Stat3. We find that …
(EGF) into mice resulted in the appearance, within minutes, of several tyrosine-
phosphorylated proteins in liver nuclei. Two of these proteins have been identified as the
transcription factors p91/p84 (Stat1 alpha/1 beta)(Ruff-Jamison, S., Chen, K., and Cohen,
S.(1993) Science 261, 1733-1736). We have now identified, by Western blotting and
immunoprecipitation, an additional EGF-modulated transcription factor, Stat3. We find that …