Rat hepatic stellate cells contribute to the acute-phase response with increased expression of α1 (I) and α1 (IV) collagens, tissue inhibitor of metalloproteinase-1, and …
The acute-phase response (APR) represents a systemic reaction of the organism to multiple
nonspecific inflammatory stimuli. In general, it is protective for the host, and hepatocytes are
the main cells responding with alterations in the expression of a set of liver-specific proteins
named the acute-phase proteins. We have previously shown that although a turpentine-
induced APR is not fibrogenic per se, it enhances collagen deposition in rats treated with
CCl4 and up-regulates expression of hepatic α1 (I) collagen and tissue inhibitor of …
nonspecific inflammatory stimuli. In general, it is protective for the host, and hepatocytes are
the main cells responding with alterations in the expression of a set of liver-specific proteins
named the acute-phase proteins. We have previously shown that although a turpentine-
induced APR is not fibrogenic per se, it enhances collagen deposition in rats treated with
CCl4 and up-regulates expression of hepatic α1 (I) collagen and tissue inhibitor of …
