Adenovirus–Mediated Expression of Cytokine–Induced Neutrophil Chemoattractant in Rat Liver Induces A Neutrophilic Hepatitis
JJ Maher, MK Scott, JM Saito, MC Burton - Hepatology, 1997 - journals.lww.com
Abstract C–X–C chemokines are potent chemoattractants that are believed to mediate
neutrophilic inflammation in several organs. Recent studies suggest a role for C–X–C
chemokines in the pathogenesis of neutrophilic hepatitis but do not prove causation. We
investigated the biological consequences of hepatic chemokine production in vivo by
transiently overexpressing cytokine–induced neutrophil chemoattractant (CINC), a member
of the C–X–C chemokine family, in intact rats. Rats were injected intraportally with a …
neutrophilic inflammation in several organs. Recent studies suggest a role for C–X–C
chemokines in the pathogenesis of neutrophilic hepatitis but do not prove causation. We
investigated the biological consequences of hepatic chemokine production in vivo by
transiently overexpressing cytokine–induced neutrophil chemoattractant (CINC), a member
of the C–X–C chemokine family, in intact rats. Rats were injected intraportally with a …
