Platelets exhibit archetypal structures and functions enabling their roles as multifunctional
host defense cells. Beyond roles in hemostasis and wound repair, platelets sense and
respond to pathogens through mechanisms including pattern recognition, early trafficking to
sites of infection, direct antimicrobial functions, and potentiation of innate and adaptive
immune mechanisms. Insufficient platelet quantity and dysfunctions in platelet quality
increase the risk of infections or worsen severity. Moreover, certain pathogens may subvert …