[HTML][HTML] Estrogen receptor-mediated activation of the serum response element in MCF-7 cells through MAPK-dependent phosphorylation of Elk-1
R Duan, W Xie, RC Burghardt, S Safe - Journal of Biological Chemistry, 2001 - ASBMB
17β-Estradiol (E2) induces c-fosprotooncogene expression in MCF-7 human breast cancer
cells, and deletion analysis of the c-fos promoter showed that the serum response element
(SRE) at− 325 to− 296 was E2-responsive. The mechanism of ligand-activated estrogen
receptor α (ERα)-dependent activation of gene expression through the SRE was determined
by mutational analysis of the promoter, analysis of mitogen-activated protein kinase (MAPK)
pathway activation by E2, and transforming growth factor α (TGF-α) as a positive control. In …
cells, and deletion analysis of the c-fos promoter showed that the serum response element
(SRE) at− 325 to− 296 was E2-responsive. The mechanism of ligand-activated estrogen
receptor α (ERα)-dependent activation of gene expression through the SRE was determined
by mutational analysis of the promoter, analysis of mitogen-activated protein kinase (MAPK)
pathway activation by E2, and transforming growth factor α (TGF-α) as a positive control. In …
