[HTML][HTML] The NF-κB repressing factor is involved in basal repression and interleukin (IL)-1-induced activation of IL-8 transcription by binding to a conserved NF-κB …
M Nourbakhsh, S Kälble, A Dörrie, H Hauser… - Journal of Biological …, 2001 - ASBMB
Interleukin (IL)-8, a prototypic chemokine, is rapidly induced by the pro-inflammatory
cytokine IL-1 but is barely detectable in noninduced cells. Although there is clear evidence
that the transcription factor NF-κB plays a central role in inducible IL-8 transcription, very little
is known about the cis-elements and trans-acting factors involved in silencing of the IL-8
promoter. By sequence comparison with the interferon-β promoter, we found a negative
regulatory element (NRE) in the IL-8 promoter overlapping partially with the NF-κB response …
cytokine IL-1 but is barely detectable in noninduced cells. Although there is clear evidence
that the transcription factor NF-κB plays a central role in inducible IL-8 transcription, very little
is known about the cis-elements and trans-acting factors involved in silencing of the IL-8
promoter. By sequence comparison with the interferon-β promoter, we found a negative
regulatory element (NRE) in the IL-8 promoter overlapping partially with the NF-κB response …