Induction of monocyte chemoattractant protein-1 by albumin is mediated by nuclear factor κB in proximal tubule cells
Y WANG, GK RANGAN, YC TAY… - Journal of the …, 1999 - journals.lww.com
The transcription and translation of monocyte chemoattractant protein-1 (MCP-1), a CC
chemokine, are increased in proximal tubule epithelial cells (PTC) stimulated with
pathophysiologically relevant concentrations of albumin. The purpose of this study was to
investigate whether nuclear factor κB (NFκB)/Rel proteins play a role in albumin-induced
MCP-1 transcription. Confluent monolayers of rat PTC in primary culture were stimulated
with delipidated bovine serum albumin. NFκB, the NFκB inhibitory protein (IκB), and MCP-1 …
chemokine, are increased in proximal tubule epithelial cells (PTC) stimulated with
pathophysiologically relevant concentrations of albumin. The purpose of this study was to
investigate whether nuclear factor κB (NFκB)/Rel proteins play a role in albumin-induced
MCP-1 transcription. Confluent monolayers of rat PTC in primary culture were stimulated
with delipidated bovine serum albumin. NFκB, the NFκB inhibitory protein (IκB), and MCP-1 …