Cytoskeletal interactions with the leukocyte integrin β2 cytoplasmic tail: activation-dependent regulation of associations with talin and α-actinin
R Sampath, PJ Gallagher, FM Pavalko - Journal of Biological Chemistry, 1998 - ASBMB
Circulating leukocytes are nonadherent but bind tightly to endothelial cells following
activation. The increased avidity of leukocyte integrins for endothelial ligands following
activation is regulated, in part, by interaction of the β2 subunit cytoplasmic tail with the actin
cytoskeleton. We propose a mechanism to explain how tethering of the actin cytoskeleton to
leukocyte integrins is regulated. In resting leukocytes, β2 integrins are constitutively linked to
the actin cytoskeleton via the protein talin. Activation of cells induces proteolysis of talin and …
activation. The increased avidity of leukocyte integrins for endothelial ligands following
activation is regulated, in part, by interaction of the β2 subunit cytoplasmic tail with the actin
cytoskeleton. We propose a mechanism to explain how tethering of the actin cytoskeleton to
leukocyte integrins is regulated. In resting leukocytes, β2 integrins are constitutively linked to
the actin cytoskeleton via the protein talin. Activation of cells induces proteolysis of talin and …
