Comparative studies of Nsc and Fmoc as Nα‐protecting groups for SPPS
R Ramage, L Jiang, YD Kim, K Shaw… - Journal of Peptide …, 1999 - Wiley Online Library
R Ramage, L Jiang, YD Kim, K Shaw, JL Park, HJ Kim
Journal of Peptide Science: An Official Publication of the …, 1999•Wiley Online Library(4‐Nitrophenyl) sulfonylethoxycarbonyl (Nsc) is an alternative base‐labile Nα‐protecting
group to 9‐fluorenylmethoxycarbonyl (Fmoc) for amino acids. The UV spectrum of the Nsc
group exhibits moderate absorption at 380 nm which is excellent for real‐time monitoring of
the deprotection process. It also decreases the rearrangement of X‐Asp, which can be a
serious problem in SPPS. Copyright© 1999 European Peptide Society and John Wiley &
Sons, Ltd.
group to 9‐fluorenylmethoxycarbonyl (Fmoc) for amino acids. The UV spectrum of the Nsc
group exhibits moderate absorption at 380 nm which is excellent for real‐time monitoring of
the deprotection process. It also decreases the rearrangement of X‐Asp, which can be a
serious problem in SPPS. Copyright© 1999 European Peptide Society and John Wiley &
Sons, Ltd.
Abstract
2‐(4‐Nitrophenyl)sulfonylethoxycarbonyl (Nsc) is an alternative base‐labile Nα‐protecting group to 9‐fluorenylmethoxycarbonyl (Fmoc) for amino acids. The UV spectrum of the Nsc group exhibits moderate absorption at 380 nm which is excellent for real‐time monitoring of the deprotection process. It also decreases the rearrangement of X‐Asp, which can be a serious problem in SPPS. Copyright © 1999 European Peptide Society and John Wiley & Sons, Ltd.
Wiley Online Library