[HTML][HTML] Protein-tyrosine phosphatase Shp-1 is a negative regulator of IL-4-and IL-13-dependent signal transduction
SJ Haque, P Harbor, M Tabrizi, T Yi… - Journal of Biological …, 1998 - ASBMB
Binding of interleukin (IL)-4 to its transmembrane receptor results in the Jak-mediated
tyrosine phosphorylation of a number of protein components of the IL-4 signaling cascade,
including Jak1, Jak2, Jak3, Tyk2, IL-4Rα, IRS-1, IRS-2, and Stat6 in appropriate cell types.
However, the protein-tyrosine phosphatases (PTPs) that dephosphorylate these proteins
and terminate signaling remained unidentified. We have noted that IL-4-dependent
activation of Stat6 is sustained longer in fibroblasts than in lymphoid cells. Because Shp-1 …
tyrosine phosphorylation of a number of protein components of the IL-4 signaling cascade,
including Jak1, Jak2, Jak3, Tyk2, IL-4Rα, IRS-1, IRS-2, and Stat6 in appropriate cell types.
However, the protein-tyrosine phosphatases (PTPs) that dephosphorylate these proteins
and terminate signaling remained unidentified. We have noted that IL-4-dependent
activation of Stat6 is sustained longer in fibroblasts than in lymphoid cells. Because Shp-1 …
