Suppression of experimental autoimmune myasthenia gravis by epitope-specific neonatal tolerance to synthetic region α146-162 of acetylcholine receptor
M Shenoy, M Oshima, MZ Atassi… - Clinical immunology and …, 1993 - Elsevier
A gene conversion event between Ebb and Abb in the B6. CH-2bm12 (bm12) strain, which
alters three amino acids in the C-terminal half of the first domain of Abb (Ile-67→ Phe; Arg-
70→ Gln; Thr-71→ Lys) resulted in resistance to experimental autoimmune myasthenia
gravis (EAMG) pathogenesis. To study the effect of bm12 mutation on the T-cell responses to
epitopes of acetylcholine receptor (AChR)-α subunit, C57BL6 (B6) and bm12 mice were
primed with Torpedo californica AChR, and the profiles of T-lymphocyte proliferation were …
alters three amino acids in the C-terminal half of the first domain of Abb (Ile-67→ Phe; Arg-
70→ Gln; Thr-71→ Lys) resulted in resistance to experimental autoimmune myasthenia
gravis (EAMG) pathogenesis. To study the effect of bm12 mutation on the T-cell responses to
epitopes of acetylcholine receptor (AChR)-α subunit, C57BL6 (B6) and bm12 mice were
primed with Torpedo californica AChR, and the profiles of T-lymphocyte proliferation were …