The development of autonomic innervation in bone and joints of the rat

G Sisask, A Bjurholm, M Ahmed… - Journal of the autonomic …, 1996 - Elsevier
The development of autonomic nerves in the hindlimb skeleton, was studied in rats from
gestational day (G) 15 to postnatal day (P) 24 by immunoreactivity to neuropeptide Y (NPY)
and vasoactive intestinal peptide (VIP). Control labelling with antisera to neurofilaments,
protein gene-product 9.5 (PGP 9.5), and nerve terminals, synaptophysin (SYN), showed
nerve fibres at G15 and nerve terminals at G19 in the perichondrial tissue. From P4, nerve
fibres and terminals were observed within the bone organ. Noradrenergic sympathetic …