Elimination of germ cells via apoptosis occurs spontaneously under normal physiologic
conditions and is often heightened after chemical-induced testicular injury. Though many
different apoptosis-related elements have been identified in the testis, the molecular and
cellular mechanisms that regulate germ cell apoptosis are not thoroughly understood. In this
review, the role of germ cell apoptosis in spermatogenesis and possible key regulators of
apoptosis is described. The involvement of the Fas-signaling pathway between Sertoli cells …