[HTML][HTML] Transmembrane phosphoprotein Cbp positively regulates the activity of the carboxyl-terminal Src kinase, Csk
S Takeuchi, Y Takayama, A Ogawa, K Tamura… - Journal of Biological …, 2000 - ASBMB
Csk (carboxyl-terminalSrc kinase) is a cytoplasmic tyrosine kinase that phosphorylates a
critical tyrosine residue in each of the Src family kinases (SFKs) to inhibit their activities.
Recently, we identified a transmembrane protein, Cbp (Csk-binding protein), that, when
phosphorylated, can recruit Csk to the membrane where the SFKs are located. The Cbp-
mediated relocation of Csk to the membrane may play a role in turning off the signaling
events initiated by SFKs. To further characterize the Csk-Cbp interaction, we have generated …
critical tyrosine residue in each of the Src family kinases (SFKs) to inhibit their activities.
Recently, we identified a transmembrane protein, Cbp (Csk-binding protein), that, when
phosphorylated, can recruit Csk to the membrane where the SFKs are located. The Cbp-
mediated relocation of Csk to the membrane may play a role in turning off the signaling
events initiated by SFKs. To further characterize the Csk-Cbp interaction, we have generated …
