Drug metabolism and variability among patients in drug response
GR Wilkinson - New England Journal of Medicine, 2005 - Mass Medical Soc
GR Wilkinson
New England Journal of Medicine, 2005•Mass Medical SocDifferences in drug responsiveness are common, often leading to challenges in optimizing
the dosage regimen for a particular patient. Recent advances provide a rational framework
for understanding many interpatient differences in drug disposition and their clinical
consequences. This article focuses on the cytochrome P-450 enzymes, a superfamily of
microsomal drug-metabolizing enzymes that play an important role in oxidative drug
metabolism.
the dosage regimen for a particular patient. Recent advances provide a rational framework
for understanding many interpatient differences in drug disposition and their clinical
consequences. This article focuses on the cytochrome P-450 enzymes, a superfamily of
microsomal drug-metabolizing enzymes that play an important role in oxidative drug
metabolism.
Differences in drug responsiveness are common, often leading to challenges in optimizing the dosage regimen for a particular patient. Recent advances provide a rational framework for understanding many interpatient differences in drug disposition and their clinical consequences. This article focuses on the cytochrome P-450 enzymes, a superfamily of microsomal drug-metabolizing enzymes that play an important role in oxidative drug metabolism.
The New England Journal Of Medicine