[HTML][HTML] Fibromodulin-null mice have abnormal collagen fibrils, tissue organization, and altered lumican deposition in tendon
L Svensson, A Aszódi, FP Reinholt, R Fässler… - Journal of Biological …, 1999 - ASBMB
Fibromodulin is a member of a family of connective tissue glycoproteins/proteoglycans
containing leucine-rich repeat motifs. Several members of this gene family bind to fibrillar
collagens and are believed to function in the assembly of the collagen network in connective
tissues. Here we show that mice lacking a functional fibromodulin gene exhibit an altered
morphological phenotype in tail tendon with fewer and abnormal collagen fiber bundles. In
fibromodulin-null animals virtually all collagen fiber bundles are disorganized and have an …
containing leucine-rich repeat motifs. Several members of this gene family bind to fibrillar
collagens and are believed to function in the assembly of the collagen network in connective
tissues. Here we show that mice lacking a functional fibromodulin gene exhibit an altered
morphological phenotype in tail tendon with fewer and abnormal collagen fiber bundles. In
fibromodulin-null animals virtually all collagen fiber bundles are disorganized and have an …
