Integrins, adhesion and apoptosis
JE Meredith, MA Schwartz - Trends in cell biology, 1997 - cell.com
JE Meredith, MA Schwartz
Trends in cell biology, 1997•cell.comIntegrin-mediated adhesion to extracellular matrix proteins is required for survival of many
cell types. This phenomenon appears to be a mechanism of tumour suppression and to
participate in embryogenesis. Here, our current understanding of how integrin-dependent
signals prevent apoptosis and implications of anchorage-dependent survival for
development, physiology and pathology are discussed.
cell types. This phenomenon appears to be a mechanism of tumour suppression and to
participate in embryogenesis. Here, our current understanding of how integrin-dependent
signals prevent apoptosis and implications of anchorage-dependent survival for
development, physiology and pathology are discussed.
Integrin-mediated adhesion to extracellular matrix proteins is required for survival of many cell types. This phenomenon appears to be a mechanism of tumour suppression and to participate in embryogenesis. Here, our current understanding of how integrin-dependent signals prevent apoptosis and implications of anchorage-dependent survival for development, physiology and pathology are discussed.
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