Homocysteine provokes leukocyte–endothelium interaction by downregulation of nitric oxide
D Pruefer, R Scalia, AM Lefer - General Pharmacology: The Vascular …, 1999 - Elsevier
Recent evidence indicates that chronic hyperhomocysteinemia, which is found in from 9 to
15% of the general population, is an independent risk factor for the development of
atherosclerosis. We sought to elucidate the mechanism by which exposure of the vascular
wall to high levels of homocysteine initiates this inflammatory reaction. We examined the
acute effect of homocysteine on endothelial dysfunction in isolated rat arteries and on
microcirculatory leukocyte–endothelium interaction in vivo. Intravital microscopy of rat …
15% of the general population, is an independent risk factor for the development of
atherosclerosis. We sought to elucidate the mechanism by which exposure of the vascular
wall to high levels of homocysteine initiates this inflammatory reaction. We examined the
acute effect of homocysteine on endothelial dysfunction in isolated rat arteries and on
microcirculatory leukocyte–endothelium interaction in vivo. Intravital microscopy of rat …