Gene expression of the transcription factor NF-κ B in hippocampus: regulation by synaptic activity
PJ Meberg, WR Kinney, EG Valcourt… - Molecular brain …, 1996 - Elsevier
NF-κ B is a potent transcriptional activator that resides in latent form in the cytoplasm
complexed to its inhibitor I κ B. Phosphorylation of I κ B by protein kinase C (PKC) releases
NF-κ B, enabling its translocation to the nucleus. Since PKC can activate NF-κ B and PKC is
activated by long-term potentiation (LTP), we investigated NF-κ B expression after
hippocampal LTP induced in vivo. We first described the expression of the NF-κ B subunits,
p50 and p65, and I κ B α mRNAs, in each cell field of the hippocampus. In other brain …
complexed to its inhibitor I κ B. Phosphorylation of I κ B by protein kinase C (PKC) releases
NF-κ B, enabling its translocation to the nucleus. Since PKC can activate NF-κ B and PKC is
activated by long-term potentiation (LTP), we investigated NF-κ B expression after
hippocampal LTP induced in vivo. We first described the expression of the NF-κ B subunits,
p50 and p65, and I κ B α mRNAs, in each cell field of the hippocampus. In other brain …