[HTML][HTML] IKKγ serves as a docking subunit of the IκB kinase (IKK) and mediates interaction of IKK with the human T-cell leukemia virus Tax protein
The tax gene product of human T-cell leukemia virus type I induces activation of transcription
factor NF-κB, which contributes to deregulated expression of various cellular genes. Tax
expression triggers persistent phosphorylation and degradation of the NF-κB inhibitory
proteins IκBα and IκBβ, resulting in constitutive nuclear expression of NF-κB. Recent studies
demonstrate that Tax activates the IκB kinase (IKK), although the underlying mechanism
remains unclear. In this report, we show that Tax physically interacts with a regulatory …
factor NF-κB, which contributes to deregulated expression of various cellular genes. Tax
expression triggers persistent phosphorylation and degradation of the NF-κB inhibitory
proteins IκBα and IκBβ, resulting in constitutive nuclear expression of NF-κB. Recent studies
demonstrate that Tax activates the IκB kinase (IKK), although the underlying mechanism
remains unclear. In this report, we show that Tax physically interacts with a regulatory …