[HTML][HTML] IKKγ mediates the interaction of cellular IκB kinases with the tax transforming protein of human T cell leukemia virus type 1
ZL Chu, YA Shin, JM Yang, JA DiDonato… - Journal of Biological …, 1999 - ASBMB
The Tax oncoprotein of human T cell leukemia virus type 1 constitutively activates
transcription factor NF-κB by a mechanism involving Tax-induced phosphorylation of IκBα, a
labile cytoplasmic inhibitor of NF-κB. To trigger this signaling cascade, Tax associates stably
with and persistently activates a cellular IκB kinase (IKK) containing both catalytic (IKKα and
IKKβ) and noncatalytic (IKKγ) subunits. We now demonstrate that IKKγ enables Tax to dock
with the IKKβ catalytic subunit, resulting in chronic IκB kinase activation. Mutations in either …
transcription factor NF-κB by a mechanism involving Tax-induced phosphorylation of IκBα, a
labile cytoplasmic inhibitor of NF-κB. To trigger this signaling cascade, Tax associates stably
with and persistently activates a cellular IκB kinase (IKK) containing both catalytic (IKKα and
IKKβ) and noncatalytic (IKKγ) subunits. We now demonstrate that IKKγ enables Tax to dock
with the IKKβ catalytic subunit, resulting in chronic IκB kinase activation. Mutations in either …