[HTML][HTML] Inhibition of interleukin-1-stimulated NF-κB RelA/p65 phosphorylation by mesalamine is accompanied by decreased transcriptional activity
LJ Egan, DC Mays, CJ Huntoon, MP Bell… - Journal of Biological …, 1999 - ASBMB
Nuclear factor κB (NF-κB) is an inducible transcription factor that regulates genes important
in immunity and inflammation. The activity of NF-κB is highly regulated: transcriptionally
active NF-κB proteins are sequestered in the cytoplasm by inhibitory proteins, IκB. A variety
of extracellular signals, including interleukin-1 (IL-1), activate NF-κB by inducing
phosphorylation and degradation of IκB, allowing nuclear translocation and DNA binding of
NF-κB. Many of the stimuli that activate NF-κB by inducing IκB degradation also cause …
in immunity and inflammation. The activity of NF-κB is highly regulated: transcriptionally
active NF-κB proteins are sequestered in the cytoplasm by inhibitory proteins, IκB. A variety
of extracellular signals, including interleukin-1 (IL-1), activate NF-κB by inducing
phosphorylation and degradation of IκB, allowing nuclear translocation and DNA binding of
NF-κB. Many of the stimuli that activate NF-κB by inducing IκB degradation also cause …