The effect of dexamethasone on the expression of activated NF-κB in adjuvant arthritis
PW Tsao, T Suzuki, R Totsuka, T Murata… - Clinical immunology and …, 1997 - Elsevier
The transcription factor NF-κB plays a significant role in inflammatory diseases. In this study
we have investigated the expression of activated NF-κB p65 subunit in the rat adjuvant
arthritis model in a 28-day time-course experiment using immunohistochemistry. The
expression of p65 was detected in the synovial lining layer and around the blood vessels in
the inflamed synovium as early as Day 3 post-adjuvant injection. The cells that expressed
p65 in the synovial lining were thought to be macrophage-like synoviocytes. The expression …
we have investigated the expression of activated NF-κB p65 subunit in the rat adjuvant
arthritis model in a 28-day time-course experiment using immunohistochemistry. The
expression of p65 was detected in the synovial lining layer and around the blood vessels in
the inflamed synovium as early as Day 3 post-adjuvant injection. The cells that expressed
p65 in the synovial lining were thought to be macrophage-like synoviocytes. The expression …