[HTML][HTML] Sulindac inhibits activation of the NF-κB pathway
Y Yamamoto, MJ Yin, KM Lin, RB Gaynor - Journal of Biological Chemistry, 1999 - ASBMB
Sulindac is a non-steroidal anti-inflammatory agent that is related both structurally and
pharmacologically to indomethacin. In addition to its anti-inflammatory properties, sulindac
has been demonstrated to have a role in the prevention of colon cancer. Both its growth
inhibitory and anti-inflammatory properties are due at least in part to its ability to decrease
prostaglandin synthesis by inhibiting the activity of cyclooxygenases. Recently, we
demonstrated that both aspirin and sodium salicylate, but not indomethacin, inhibited the …
pharmacologically to indomethacin. In addition to its anti-inflammatory properties, sulindac
has been demonstrated to have a role in the prevention of colon cancer. Both its growth
inhibitory and anti-inflammatory properties are due at least in part to its ability to decrease
prostaglandin synthesis by inhibiting the activity of cyclooxygenases. Recently, we
demonstrated that both aspirin and sodium salicylate, but not indomethacin, inhibited the …