Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases
PL Opresko, C von Kobbe, JP Laine, J Harrigan… - Journal of Biological …, 2002 - ASBMB
Werner syndrome is a human premature aging disorder displaying cellular defects
associated with telomere maintenance including genomic instability, premature senescence,
and accelerated telomere erosion. The yeast homologue of the Werner protein (WRN),
Sgs1, is required for recombination-mediated lengthening of telomeres in telomerase-
deficient cells. In human cells, we report that WRN co-localizes and physically interacts with
the critical telomere maintenance protein TRF2. This interaction is mediated by the RecQ …
associated with telomere maintenance including genomic instability, premature senescence,
and accelerated telomere erosion. The yeast homologue of the Werner protein (WRN),
Sgs1, is required for recombination-mediated lengthening of telomeres in telomerase-
deficient cells. In human cells, we report that WRN co-localizes and physically interacts with
the critical telomere maintenance protein TRF2. This interaction is mediated by the RecQ …
