[HTML][HTML] Phosphorylation-dependent Block of Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel by Exogenous R Domain Protein (∗)
J Ma, JE Tasch, T Tao, J Zhao, J Xie, ML Drumm… - Journal of Biological …, 1996 - ASBMB
The cystic fibrosis transmembrane conductance regulator (CFTR) constitutes a linear
conductance chloride channel, which is regulated by cAMP-dependent protein kinase
phosphorylation at multiple sites located in the intracellular regulatory (R) domain. Studies in
a lipid bilayer system, reported here, provide evidence for the control of CFTR chloride
channel by its R domain. The exogenous R domain protein (encoded by exon 13 plus 85
base pairs of exon 14) interacted specifically with the CFTR molecule and inhibited the …
conductance chloride channel, which is regulated by cAMP-dependent protein kinase
phosphorylation at multiple sites located in the intracellular regulatory (R) domain. Studies in
a lipid bilayer system, reported here, provide evidence for the control of CFTR chloride
channel by its R domain. The exogenous R domain protein (encoded by exon 13 plus 85
base pairs of exon 14) interacted specifically with the CFTR molecule and inhibited the …
